The endoplasmic reticulum (ER) is classically linked to metabolic homeostasis via the activation of unfolded protein response (UPR), which is instructed by multiple transcriptional regulatory cascades ...
"Study links BAP1 protein to tumor suppression in kidney, eye, bile duct and mesothelioma cancers." ScienceDaily. www.sciencedaily.com / releases / 2018 / 09 / 180910142453.htm (accessed December 27, ...
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that ...
Identifying individuals with primary central nervous system tumors at risk for hereditary cancer syndromes using the Utah Population Database. This is an ASCO Meeting Abstract from the 2021 ASCO ...
The loss of BAP1 protein expression is associated with an increased risk for death in patients with low-risk clear-cell renal cell carcinoma, according to study results. BAP1 mutations — which are ...
Patients with BAP1-mutated renal cell carcinoma who were treated with Lynparza obtained responses with favorable side effect profiles. Patients with renal cell carcinoma (RCC) whose tumors had gene ...
A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The ...
Mesothelioma is a rare, aggressive cancer affecting the lining that surrounds organs. The most common form of the disease, pleural mesothelioma, develops in the tissue lining the lungs. The disease is ...
HOUSTON - Researchers at The University of Texas MD Anderson Cancer Center have shown how BRCA-associated protein 1 (BAP1) serves as a tumor suppressor gene in kidney, eye, bile duct, mesothelioma and ...
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