Cell signalling pathways are central to maintaining cellular homeostasis and regulating essential functions such as proliferation, apoptosis, and repair. In both cancer and neurodegenerative diseases, ...

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome — a cell’s complete set of DNA — is most vulnerable while it is being duplicated ...

The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...

When you consider the vast number of signaling pathways needed to coordinate the 37.2 trillion cells in the human body, it’s difficult to think of our normal health and functioning as anything less ...

Dr Sebastian Guettler’s group is researching the ways in which certain enzymes, known as ADP-ribosyltransferases (ARTs), control cell function. Professor Sebastian Guettler is Deputy Head of the ...

Hair loss and graying, the earliest visible hallmarks of skin aging, result from the functional decline of hair follicle stem ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation.

A study by the Mildred Scheel Early Career Center group led by Dr. Mohamed Elgendy at the TUD Faculty of Medicine provides ...

Immunotherapy has revolutionized the way physicians treat patients. Previously, chemotherapy was the standard-of-care with the goal to eliminate tumor cells by dysregulating their ability to ...

Dr Sebastian Guettler’s group is researching the ways in which certain enzymes, known as ADP-ribosyltransferases (ARTs), control cell function. Our group utilises biochemistry, structural biology and ...