Differential interference contrast microscopy images show protein-RNA vesicles created in the lab. The vesicles -- hollow, spherical sacks -- were made without traditional lipid building blocks. The ...

Differential interference contrast microscopy (DICM) enables visualization of transparent samples such as live, unstained cells by converting optical phase due to variations of the sample’s optical ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

The use of high-resolution bright-field microscopy is essential for cellular-scale biological research, but this technique has limitations due to low image contrast. Using dyes on the sample can ...

Light microscopy is a key tool that scientists use to image cells, organelles, subcellular structures, and molecules such as proteins and nucleic acids. Because visible light leaves biological ...

Light microscopy is used to make small structures and samples visible by providing a magnified image of how they interact with visible light, e.g., their absorption, reflection and scattering. This is ...