In an age when the majority of monogenic human disease genes have been identified, one of the challenges for the coming generation of human geneticists will be to resolve complex polygenic and ...
Many common health conditions arise due to a combination of genetic factors and lifestyle-related behaviors. People’s understanding of the multifactorial nature of health conditions has implications ...
Correspondence to Dr Sally Hopewell, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7LD, UK; sally.hopewell{at}csm.ox.ac.uk Objective ...
Spina bifida is among the most common and debilitating neural tube defects, affecting approximately 1 in every 2,875 newborns in the United States. This congenital malformation disrupts the normal ...
Cardiovascular morbidity is a major burden in patients with type 2 diabetes. In the Steno-2 Study, we compared the effect of a targeted, intensified, multifactorial intervention with that of ...
In some cases, more than one factor may be responsible for causing the birth defect. For example genes form both parents may interact with one another to produce an undesirable effect in the presence ...
Implementing a range of interventions can help cut patient falls and improve safety Subscribe today for unlimited access to 6,000+ clinical articles, learning units, procedures, AI-powered tools, ...
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