The proteome is an incredibly rich and dynamic source of biological information, key to understanding how cells function in sickness and health. Genes and genomes give hints as to what might happen in ...

Following on from his exposé of the dearth of specificity in our vocabulary surrounding the proteome and his emphasis that individual proteoforms should be the focus of our proteomic investigations, ...

The proteome is the entire set of proteins within a cell, tissue or organism. The human proteome is estimated to contain over 75,000 different proteins, with over 20,000 characterised to date. Unlike ...

Proteomics is a rapidly expanding field, aided by improvements in instrumentation accuracy and sensitivity, size and affordability. This offers many possibilities for the increasing interest in ...

Since the advent of the Human Genome Project, scientists have expanded efforts to map complete biological datasets that encompass entire molecular families, such as DNA, RNA, proteins, and metabolites ...

The term “proteome” was coined by an Australian PhD student, Marc Wilkins, in a 1994 symposium held in Siena, Italy. 2 It is a blanket term that refers to all of the proteins that an organism can ...

Despite their sophistication and power, traditional proteomics technologies have failed to provide comprehensive coverage. For example, with conventional mass spectrometry, a single experiment ...

Aneuploidies of chromosome 17 in breast cancer: Relative prevalence in a series of 170 patients from Córdoba, Argentina, studied with fluorescent in-situ hybridization (FISH) ...

In a recent study published in Nature Metabolism, researchers investigate systemic proteome adaptations to one week of fasting in humans. Study: Systemic proteome adaptions to 7-day complete caloric ...