Adopting a Quality by Design (QbD) approach for wet granulation requires manufacturers to comprehend the correlation between process variables, such as powder characteristics and equipment ...

The authors prepared granules containing cinnarizine using polyethylene glycol 6000 as a melting binder and lactose monohydrate as hydrophilic filler. The effects of binder concentration and size were ...

Granulation and compression are two very important processes that are carried out extensively by most pharmaceutical companies. However, the theory of granulation is little understood and the ...

Tablets and capsules are most popular oral solid dosage forms to administer a therapeutic drug. Formulation such as pills, troches, cachets and pellets are secondary to tablets, which contain the ...

Granulation is a critical unit operation in pharmaceutical manufacturing, where fine powders are agglomerated into granules to improve flow properties, uniformity, and compaction performance. The ...

Dry granulation, also called roller compaction, has been a popular method in recent years and has many applications. The powder is compressed between revolving rollers to generate flakes. The flakes ...

The last decade has seen an impressive growth in the research and mechanistic understanding of the agglomeration process, along with attempts to model the process. There have even been a few papers on ...