Our group focuses on the structural basis of human pre-mRNA processing, including: splicing modulation by compounds with antitumour properties, ubiquitination in splicing and DNA repair and helicases.

Researchers have puzzled over the neurodegenerative disorder Alzheimer’s disease for decades, but treatments to stop or reverse the disease’s effects on the brain have remained elusive. Scientists at ...

In cancers such as breast cancer where immunotherapy responses are seen in a small subset of patients, inducing T-cell responses against common mis-splicing events that generate neo-antigens holds ...