T cell development is a tightly regulated process that transforms immature thymocytes into mature T cells with distinct functionalities. In the thymus, precursor cells undergo a series of selection ...

Descriptions of the embryo go back at least to the time of Aristotle, but it has only been since the late 19 th century and early 20 th century that advances in experimental approaches allowed ...

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During ...

B cells were first characterized in the 1960s and early 1970s, when Max Cooper and Robert Good showed that surgical removal of the bursa of Fabricius (a primary immune organ in birds) rendered ...

Understanding how these cells develop and function is like decoding a complex puzzle. "By perfecting stem cell methods that mimic the development of the normal blood stem cells found in our bodies we ...

The new method offers researchers a powerful new platform to investigate the molecular mechanisms that control oogenesis, the process by which egg cells develop, and lays important groundwork for ...

To achieve this progress, biologic production has had to reinvent itself. Although biologics were once sourced directly from donated blood plasma or cells, the backbone of this process is now a ...

Researchers have created a way to guide and control the development of stem cells into specific tissues and organs, opening the door to developing a means of one day tackling complex diseases like ...

Activation and expansion are essential for success in both autologous and allogeneic therapies. Gamma-delta (γδ) T cells make up on average 4–5% of T cells found in human peripheral blood (1). Two ...

Developing bioassay methods requires a new approach for cell and gene therapy drug development. As cell-based methods continue to evolve in support of gene therapies to assess product potency through ...

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life. Each of us starts ...