For the complement system to cause AMD, there must be initiation (a ‘trigger’), amplification, and local retinal damage caused by the process. The alternative pathway of the complement system is ...

Complement molecules are the immune proteins responsible for identifying bacteria, viruses, and other foreign invaders as they circulate through our bodies. Their function helps lymphocytes to locate ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense against ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 72, No. 6 (Jun., 1975), pp. 1989-1993 (5 pages) ...

The antibody response and the complement system are major effector arms of the immune system. Both have been involved in a plethora of pathological conditions – including autoimmunity, allergy, ...

We are studying the role of the complement system in kidneys and brains during health and disease. Traditionally, major complement proteins were shown to be generated by the liver and are functional ...

Opsonic activity for Streptococcus pneumoniae mediated by the alternative and classic complement pathways and concomitant binding of activated C3 to the bacteria were measured in sera from children ...

Crippling the complement cascade in a mouse model of AD leads to more plaques, but less neurodegeneration and better function, according to a new study from Cynthia Lemere and colleagues at Brigham ...